Hemodialysis Properties of Clindamycin (7-Chloro-7-Deoxylincomycin)

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Hemodialysis properties of clindamycin (7-chloro-7-deoxylincomycin).

The effect of hemodialysis (Kolff-type machine) on clindamycin blood levels in anuric patients was studied. At 1 hr after oral ingestion of drug, blood levels ranged from 1.23 to 5.17 mug/ml and fell thereafter. Half-times for peripheral removal were 3.36 mug/ml +/- 0.22 when subjects were "off" dialysis and 3.14 mug/ml +/- 0.09 during dialysis. Their difference was not statistically significan...

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Activity against M. leprae of lincomycin and two derivatives, of amicetin, phosphonomycin and two derivatives of tetrahydronaphthylaminopropylpiperidine.

In continuing studies of drugs against Mycobacterium leprae in mice we have tested the following compounds: lincomycin, clinimycin (7( S ) -chloro-7 -deoxylincomycin, clindamycin) , U-24729A (4' -pentylN -demethyl-7 -chlorolincomycin), amicetin, phosphonomycin, ABT-29666 (1-{3-[ 4-(pchlorophenyl-azo )-5, 6, 7, 8-tetrahydro-1naphthylamino] propyl} piperidine), ABT38396 (1{3-[ 4-( 6-methoxy-3-pyr...

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ژورنال

عنوان ژورنال: Applied Microbiology

سال: 1969

ISSN: 0003-6919

DOI: 10.1128/aem.17.3.446-448.1969